10 Surprising Luteolin Supplement Side Effects 

Perhaps you have been using Luteolin to prevent cardiovascular attacks and are curious about its side effects. This article will tell you everything you need to know, including Luteolin Supplement Side Effects.

Also, the article will tell you how to use the supplement.  

Without further ado, let us get started.  

Luteolin Overview 

According to this article from frontiers, Luteolin, a flavonoid, is a supplement used to prevent cardiovascular disease attacks.

The supplement has anti-tumor, anti-oxidative, and anti-inflammatory properties, effectively preventing conditions like cardiac attacks.

Besides, those properties make it a great supplement for reducing diseases caused by inflammation.

Also, it is a crucial aspect of memory boost because of its anti-oxidative properties. Also, due to those anti-oxidative properties, it supports the nervous system.  

Is Luteolin Similar to Lutein 

While looking for information concerning Luteolin online, you could have encountered another supplement called Lutein.

Normally, these two supplements confuse users because their names are almost similar. However, they are completely different.  

Luteolin, as defined in the overview section, is a flavonoid that helps prevent diseases caused by inflammation, oxidation, and tumor.

On the other hand, Lutein is an organic pigment that aids the eyes. It is, for this reason, it is also called the eye pigment.  

Note that these two supplements do not serve the same purpose. Hence, do not confuse Lutein as an alternative of Luteolin.  

What is the best source of Luteolin? 

You can obtain healthy Luteolin from vegetables and fruits. Specifically, vegetables like broccoli, carrots, cabbages, and parsley are reliable sources of Luteolin.

Similarly, fruits like apples, chrysanthemum flowers, and pepper act as Luteolin sources.  

How does Luteolin Work?  

As mentioned earlier, Luteolin is a flavonoid. Flavonoids have properties that assist them in performing their functions.

For instance, they have anti-oxidation properties that help the body to get rid of toxins, as depicted in this study 

Additionally, Luteolin, like other flavonoids, has anti-inflammation properties. This helps them combat germs, allergens, toxins, and irritants known to cause Inflammation. As a result, it boosts the body’s immune system.  

Also, it regulates cellular activities and fights free radicals that can cause oxidative stress. Therefore, it helps the body perform efficiently. Besides, it protects the body against stressors and toxins.  

How Much Luteolin Supplement Should You Take? 

There is not enough information backing Luteolin dosage. Furthermore, the FDA does not approve the supplement for medical use.  

However, if you must use the supplement, remember that it comes in different forms, like powder, chewable tablets, and pills. Irrespective of the version you get, adhere to a dosage of 100-300 mg per serving.  

Also, consider taking the supplement in combination with others, like rutin. You may also add it to your meal to make it easier to take.  

Positive Luteolin Supplement Side Effects

1. It stabilizes the mast cells 

Our body’s defense relies on mast cells. This is because. They defend us from bacterial assault. To understand how it helps stabilize the mast cells, it is vital to recognize how the mast cells and allergies relate.

According to this study, the higher the number of allergies, the worse the situation is for mast cells.

When the situation worsens for mast cells, they produce histamine hormones, which might result in sneezing, congestion, and brain fog.  

When in this situation, taking Luteolin Supplement can help. It prevents the degeneration of mast cells, which limits the production of histamine hormones. This way, it stabilizes the mast cells.  

2. It is an antioxidant 

You already know that Luteolin is a class of reactive special flavonoids with antioxidant properties.

They are known as reactive oxygen species (ROS). Large-scale production of ROS can harm DNA, lipids, and protein.  

ROS is linked to cancer and cardiovascular diseases. This gets worse in the absence of Luteolin. However, in its presence, it prevents ROs from harming the body.

Also, it inhibits the production of ROS, thereby reducing oxidative stress.  

3. It helps with Estrogenic and Anti-Estrogenic activities

Another crucial function of Luteolin is helping bind estrogen receptors, activating their pathway. Besides, it has properties that enable it to substitute estrogen if estrogen levels drop.  

Also, being a flavonoid, it possesses some anti-estrogenic properties, especially because flavonoids have low receptor binding rates. In the absence of estrogen, it substitutes it.

However, if estrogen production is high, it competes for the receptors. While this may sound bad, it is good because it reduces the prevalence of cancers caused by high estrogen levels.  

4. It controls inflammation 

Inflammation is a normal biological response to injury, irritation, or infection. Immune cells are released from blood vessels, and mediators are released at the injury site.

The components released repair injured tissue, and eliminate foreign microbes.

Normal inflammation is fast and limited. However, prolonged inflammation can be a sign of illness. Flavonoids like luteolin help control inflammation response.

A better inflammatory response is one of the positive Luteolin supplement side effects.

5. It helps combat cancer tumors

Another one of the benefits of the Luteolin supplement is combating cancer cells. It prevents the spread of cancer cells by blocking the paths those cancer cells use to migrate from one body part to the next.  

In addition, flavonoids reduce the activity of reactive oxygen species (ROS)-scavenging enzyme activity. Studies show that it triggers the destruction of cancer cells.

6. It controls anxiety

Another one of the positive Luteolin supplement side effects is the reduction of anxiety. Administering Luteolin improves freezing behavior in stressful situations.

Some experts believe that it can be useful in managing stress from Post Traumatic Stress Disorder (PTSD).

Negative Luteolin Supplement Side Effetcs.

There are few negative Luteolin Supplement Side Effects because it is obtained from proven safe plants. However, if used incorrectly, it can pose a few health risks. Some of those risks include the following:  

1. It can exaggerate irritability 

Studies show that luteolin can increase irritability in children with certain disorders, like autism, by 50%. Hence, if your child has autism, avoid using Luteolin Supplement.  

2. It can block the effects of progesterone  

Another Luteolin supplement side effect is blocking progesterone effects. As a result, it might expose you to adverse effects if you have cervical or uterine cancer.  

3. It can worsen chemically induced colitis 

Lastly, aggravating chemically induced colitis is another Luteolin supplement side effect.

As much as it is meant to reduce colitis, misusing the supplement may worsen chemically induced colitis by inhibiting NF-kB. Inhibiting NF-kB blocks protective muscles, thereby worsening colitis.

4. It can prevent pregnancy

If you’re trying to get pregnant, the progesterone-blocking effects of Luteolin Supplement can prevent pregnancy. Avoid this supplement if you’re actively trying to start a family.


In conclusion, the Luteolin supplement has several advantages. However, if used incorrectly, it has some harmful effects.

Even though these effects lack evidence from reputable studies, it is wise to protect yourself against them. Therefore, be wary of those side effects if you consider the supplement. 

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