10 Surprising Crospovidone Side Effects

Crospovidone is a water-insoluble polyvinylpyrrolidone (PVP) used in the pharmaceutical industry to disintegrate and bind tablets. This article will tell you everything you need to know about crospovidone side effects.

It also improves the bioavailability of steroids and kills germs in wounds.

In many oral supplements and medications, agents like crospovidone are the majority of the mass of the products.

However, the inactive ingredients chosen have minimal risks of allergies and bad reactions. But, you can never be too careful.

If you’re going to learn anything about this compound, then crospovidone side effects are where you should start.

Despite its significant role in the pharmaceutical industry, there are several crospovidone side effects that we don’t discuss as often as we should.

Lucky for you, this article explains 10 such crospovidone side effects that pharmaceutical companies may fail to reveal to you.

Read on to find out all there is to know about these crospovidone side effects.

What is the mechanism of action of crospovidone?

Crospovidone belongs to a class of agents called excipients which alter the appearance of medication. Furthermore, they ensure the medication achieves the desired pharmaceutical goals.

Usually, excipients improve absorption, change the taste of the product, make the product stable, and prevent tampering with the medication.

Crospovidone acts as a disintegrating agent.

Crospovidone disintegrants act by a wicking mechanism.

They draw water into the tablet through capillary action because of its porosity.

This results in secondary swelling and rupturing the bonds in the tablet, disintegrating it.

Can inactive ingredients cause side effects?

Manufacturers of drugs usually add inactive ingredients like crospovidone to stabilize medication and improve the ability of the body to absorb active ingredients.

Most people believe it is impossible to get adverse reactions from ingredients not active in drug formulae.

While they remain unproblematic in most cases, it is not uncommon to experience side effects from inactive ingredients.

If you keep reading this article, you will find out some little-known crospovidone side effects that prove that, indeed, inactive ingredients can cause adverse reactions after use.

What is crospovidone in vitamins?

As mentioned earlier, crospovidone is an inactive ingredient added to medications.

It’s also added to vitamins to aid in the absorption of the vitamins.

Crospovidone side effects

Below are some crospovidone side effects that may take you by surprise.

#1. It may cause pulmonary vascular injury

People who inject crushed tablets with crospovidone into their bodies risk injuring their blood vessels.

A study on the lungs of people who regularly inject themselves with pharmaceutical drugs revealed coral-like particles in pulmonary vessels.

These particles were solid deposits of crospovidone that had formed inside the vessels due to prolonged use.

#2. It can trigger inflammation in the skin

Injecting this compound into your skin may cause inflammation, which manifests in the form of painful nodules or ulcers on the skin.

If your skin is sensitive and you have to use this drug, talk to your dermatologist to help you minimize the risk of inflammation.

#3. It increases the risk of hypertension

Crospovidone is a substance you should avoid if you have or are prone to high blood pressure.

By forming hardened deposits inside your blood vessels, this compound puts you at significant risk of developing hypertension.

Some symptoms of hypertension to look out for include shortness of breath, headaches, and blurry vision.

Always check the ingredients of any drugs you are taking, lest you put your health at risk.

#4. It can cause pulmonary embolism

One of the most surprising crospovidone side effects is that it can cause a pulmonary embolism.

When present in drugs, this substance can cause you to develop a blood clot in the blood vessels of your lungs.

This condition is commonly referred to as a pulmonary embolism.

If a blood clot develops in a blood vessel, chances are it will block the vessel and prevent any further blood flow within it.

Pulmonary embolism will likely manifest itself in the form of sudden shortness of breath, pale skin, rapid heartbeat, wheezing and sharp pain in your chest.

In some cases, its symptoms can be similar to those of a heart attack.

This condition may be fatal if not given immediate medical attention.

#5. It may trigger allergies

Although it is rare to develop allergies from inactive ingredients, it is not entirely impossible.

In most cases, allergies develop within the first few hours of use.

If you experience common allergy symptoms, such as itching, swelling, and hives, seek medical attention as soon as possible.

#6. You may suffer from Acute Respiratory Distress Syndrome (ARDS)

Ingesting tablets with pyrrolidone can cause irritation to your respiratory tract. This will likely manifest as a mild cough and chest pain.

However, in more severe cases, such irritation progresses into full-fledged Acute Respiratory Distress Syndrome, which in most cases will be delayed in onset for about 24 – 72 hours.

This is a common condition that causes acute respiratory failure and can lead to death in serious cases.

#7. It can burn the esophagus

As much as this reaction is quite rare, it is very possible for you to suffer burns in your esophagus as a result of ingesting crospovidone.

Should you feel any sort of irritation in your throat or stomach after using this substance, stop using it and seek medical advice.

#8. It may trigger asthma attacks

Being that this compound has the potential to cause irritation in your respiratory tract, it may also make you experience frequent asthma attacks.

Anyone with asthma should use tablets with this compound cautiously and only under the direction of their doctor.

#. It may cause aspiration pneumonia

Aspiration pneumonia is a special kind of pneumonia that occurs when you inhale something other than air into your lungs.

Bacteria in the nasal and oral pharynx can also cause it.

Although this is not very common, you can develop this form of pneumonia from ingesting oral medication with crospovidone.

This happens when particles of the drug lodge themselves in your lungs instead of passing through your esophagus.

Some common symptoms of it include chest pain, fatigue, fever, excessive sweating, breath odor, and shortness of breath.

#10. It can cause a sore throat

Did your throat suddenly become sore after you started using a product with this substance?

Well, chances are crospovidone is causing that reaction.

A few users report developing sore throats immediately after using drugs with crospovidone.

So if you are the kind of person that suffers from sore throats easily, then you should know that you may develop one from using crospovidone.


We cannot deny the role inactive ingredients like crospovidone play in making pharmaceutical products.

However, we must also mention the risk of adverse reactions from using drugs with these ingredients.

This article points out 10 of the most surprising crospovidone side effects that you may experience if you use drugs made with it.

Have a chat with your doctor before using this substance if you are prone to any of them.

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