10 Surprising Low Dose Naltrexone Side Effects

Low dose naltrexone is a widely used supplement for managing various conditions, but not without side effects. In actuality, the supplement has an amazing back story. For instance, how the compound, which was formerly used to manage opiate addiction advanced into a potentially ground-breaking treatment for treating symptoms of more than 15 distinct conditions remains fascinating.

Keep reading to discover the intriguing backstory and all about low-dose Naltrexone (LDN).

Naltrexone was initially a treatment for managing opiate and drug addiction.

To prevent heroin, as well as other opiates, from binding to opiate receptors all through the body, Naltrexone blocks these receptors.

Opioids cannot cause a “high” feeling if they do not bind to opioid receptors.

Years later, a study revealed that patients with HIV, cancer, and autoimmune illnesses might benefit further by taking Naltrexone at a considerably lower dose.

What is a Low Dose of Naltrexone?

Naltrexone, an opioid antagonist, is administered orally to prevent cells from developing opiate landing sites.

The (FDA) approves Naltrexone to manage alcohol and narcotic addictions.

This way, Naltrexone is essential  medication-assisted rehabilitation (MAR), which employs drugs to help treat alcohol and opiate use problems.

Because of its less restricted usage accessibility, Naltrexone is occasionally referred to as methadone and buprenorphine.

Sometimes, Naltrexone is incorporated into a treatment plan for obsessive-compulsive tendencies, psychotic disorders, and self-harming tendencies.

Use Naltrexone only under the prescription of a certified physician.


Studies backing up the effectiveness of Low Dose Naltrexone

Research is also underway on other cancer types, autoimmune-related diseases, and other chronic pain conditions.

It is extensively used for a range of immunological illnesses and pain-related disorders while these studies are ongoing.

Recent research demonstrates the effectiveness of Low Dose Naltrexone as a reliable, affordable treatment for immunological disease and persistent pain.

Low-dose Naltrexone (LDN) is a treatment option for MS. However; clinical research is lacking. Minimal, semi-controlled trials have made up the majority of the finished research.

Most finished trials indicate that LDN is effective and well-tolerated, but few indicate that the medical condition has improved.

LDN is not a disease-modifying medication owing to the lack of evidence supporting its efficacy in treating MS.

Discuss with your doctor or nurse about LDN’s potential usefulness, side effects, and dangers is crucial if consider using it.

Main Uses of Low Dose Naltrexone

Few significant studies are looking into low dose naltrexone.

However, when patients on a taper regimen for Naltrexone expressed relief from discomfort and exhaustion signs with a low dose of Naltrexone instead of a high dose, the advantages of low dose naltrexone were clear.

Using LDN has been investigated in clinical studies for the following ailments, to name:

  • Bowel inflammation and Bowel Disease (IBS) (IBD)
  • Lupus multiplex (MS)
  • Parkinson’s disease
  • Separation anxiety
  • Numerous cancers.
  • The Lyme disease
  • Peptic ulcer disease, Colitis, and Crohn’s disease
  • Anxiety and depression

Common Low Dose Naltrexone Side Effects

A medication may also have some unintended side effects in addition to its desired effects.

Naltrexone use is linked to many typical, minor adverse effects, like other drugs.

Most low dose naltrexone side effects are modest and self-limiting.

While not all of these adverse effects are likely, they can require medical treatment if they develop.

If any of the below low dose naltrexone side effects manifest, consult your doctor right away:

Liver damage

Up to half the patients who use naltrexone experience elevated serum levels of liver enzymes; these elevations are frequently minor and self-limited.

About 2% of people on naltrexone experience increases that exceed four times the maximum limit of usual and necessitate stopping the drug.

Naltrexone is unsuitable for usage in people with acute hepatitis or liver problems because it has the potential to result in hepatic damage when taken in excessive or massive dosages.

Conducting regular examination and tests of liver function is ideal if greater doses of Naltrexone are necessary for pharmacological efficacy.


Nausea is a typical low dose naltrexone side effect of the usage of many drugs.

Generally, naltrexone-related nausea is minimal. The presence of severe nausea could be a sign that something’s amiss.

If you suffer any of the following signs of severe nausea, seek medical help right away:

  • Chronic nausea lasting longer than two days
  • Due to sickness, you cannot eat for two days or drink for 24 h.
  • A nauseous feeling
  • A severe headache, blurred vision, or disorientation
  • Breathing problems and an elevated heartbeat
  • Severe stomach discomfort, copious diarrhea, or nausea that regurgitates
  • Sweating, pressure in the chest, jaw discomfort, or arm pain

Reduced appetite

Naltrexone can suppress appetite and lessen the allure of food.

However, appetite suppression is typically a low-dose naltrexone side effect for people who worry about greater appetite or weight gain.

Naltrexone use may result in weight loss. This is often how people try to quit smoking or initiate drugs cause sudden weight gain.

Even though many pharmacies advertise it as a weight-reduction tool, Naltrexone is often not used as a stand-alone weight-loss supplement.

How long do Low Dose Naltrexone Side Effects Last?

Moderate low-dose naltrexone side effects, such as nausea, puking, and bowel problems, typically go away a few weeks after commencing treatment or stopping the drug.

The long-term and perhaps destructive nature of some severe adverse effects (liver damage, suicidal tendencies, and hypersensitivity reactions) is unknown.


Even though liver damage with Naltrexone can also occur at low dosages, it is typical at high levels.

Along with these, there are low dose naltrexone sides effects like nausea, vomiting, stomach discomfort, loss of appetite, constipation, migraine, exhaustion, restlessness, disorientation, depression, and stress.

Confusion, delusions, distorted vision, and extreme vomiting or diarrhea are serious adverse reactions. Ensure you report immediately to a healthcare professional.

Some adverse effects could happen, although they typically don’t require medical treatment.

During therapy, these adverse effects can fade away when your body adapts to the medication.

You might also avoid or lessen some of these low dose naltrexone side effects by following the advice provided by your healthcare provider.

If any of the following adverse effects persist, consult your doctor immediately.

While using Naltrexone, stay away from alcohol, narcotics, illicit substances, any CNS depressants, and pharmaceuticals with potential interactions.

One can avoid overdose risks by eliminating these compounds.



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